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L19 Ribosomal protein leaders[1] are part of the ribosome biogenesis. They are used as an autoregulatory mechanism to control the concentration of ribosomal proteins L19, and are located in the 5′ untranslated regions of mRNAs encoding ribosomal protein L19 (rplS). L19 ribosomal protein leaders have been bioinformatically predicted in B. subtilis and other low-GC Gram-positive bacteria in the phylum Bacillota.[2] More examples that share a similar structure were predicted in Flavobacteria,[3] also using bioinformatic approaches.
| L19_leader | |
|---|---|
 Consensus secondary structure and sequence conservation of Ribosomal protein L19 leader | |
| Identifiers | |
| Symbol | L19_leader |
| Rfam | RF00556 |
| Other data | |
| RNA type | Cis-reg; leader |
| GO | GO:0010468 |
| SO | SO:0000233 |
| PDB structures | PDBe |
| L19-Flavobacteria | |
|---|---|
 Consensus secondary structure and sequence conservation of L19-Flavobacteria ribosomal protein leader | |
| Identifiers | |
| Symbol | L19-Flavobacteria |
| Rfam | RF03130 |
| Other data | |
| RNA type | Cis-reg; leader |
| SO | SO:0000837 |
| PDB structures | PDBe |
See also
editReferences
edit- ^ Zengel JM, Lindahl L (1994). Diverse mechanisms for regulating ribosomal protein synthesis in Escherichia coli. Progress in Nucleic Acid Research and Molecular Biology. Vol. 47. pp. 331–370. doi:10.1016/S0079-6603(08)60256-1. ISBN 978-0-12-540047-3. PMID 7517053.
- ^ Yao, Z; Barrick, J; Weinberg, Z; Neph, S; Breaker, R; Tompa, M; Ruzzo, WL (2007). "A computational pipeline for high-throughput discovery of cis-regulatory noncoding RNA in prokaryotes". PLOS Computational Biology. 3 (7): e126. Bibcode:2007PLSCB...3..126Y. doi:10.1371/journal.pcbi.0030126. PMC 1913097. PMID 17616982.
- ^ Eckert, I; Weinberg, Z (24 May 2020). "Discovery of 20 novel ribosomal leader candidates in bacteria and archaea". BMC Microbiology. 20 (130): 130. doi:10.1186/s12866-020-01823-6. PMC 7247131. PMID 32448158.
External links
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